Targeting Src in Mucinous Ovarian Carcinoma
نویسندگان
چکیده
منابع مشابه
Targeting SRC in mucinous ovarian carcinoma.
PURPOSE Mucinous ovarian carcinomas have a distinct clinical pattern compared with other subtypes of ovarian carcinoma. Here, we evaluated (i) stage-specific clinical significance of mucinous ovarian carcinomas in a large cohort and (ii) the functional role of Src kinase in preclinical models of mucinous ovarian carcinoma. EXPERIMENTAL DESIGN A total of 1,302 ovarian cancer patients including...
متن کاملCancer Therapy: Preclinical Targeting Src in Mucinous Ovarian Carcinoma
Purpose:Mucinous ovarian carcinomas have a distinct clinical pattern compared with other subtypes of ovarian carcinoma. Here, we evaluated (i) stage-specific clinical significance of mucinous ovarian carcinomas in a large cohort and (ii) the functional role of Src kinase in preclinical models of mucinous
متن کاملTargeting SRC and tubulin in mucinous ovarian carcinoma.
PURPOSE To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian carcinoma. EXPERIMENTAL DESIGN The in vitro and in vivo effects and molecular mechanisms of KX-01, which inhibits Src pathway and tubulin polymerization, were examined in mucinous ovarian cancer models. RESULTS In vitro studies using RMUG-S and RMUG-L cell lines showed that KX-01 inhibited cell pro...
متن کاملCancer Therapy: Preclinical Targeting Src and Tubulin in Mucinous Ovarian Carcinoma
Purpose: To investigate the antitumor effects of targeting Src and tubulin in mucinous ovarian
متن کاملMucinous epithelial ovarian carcinoma.
Mucinous tumours involving the ovary may be benign, borderline, or malignant. Malignant tumours may be primary or metastatic. Differentiation between primary and metastatic involvement of the ovary is critical for optimal patient management. Even among skilled pathologists, this distinction can be problematic, as can the distinction between borderline ovarian tumour of intestinal type and well-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2011
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-10-3176